After becoming intrigued with this information, I decided to look up to see how epigenetic therapy has been used to help people with cancer. In fact, it was found that this type of therapy helps fight against several blood cancers! Scientists used "OTX015, a member of a new class of investigational epigenetic therapies that block the activity of bromodomain and extraterminal(BET)-Bromodomain proteins" (Boltz 2014). These proteins mentioned help determine if a gene will be turned on or off. As learned in the video, the proteins attach to epigenetic flags on the genome. Any abnormal positions of the flags can be a sign of cancer and the positioning "can inappropriately turn genes on or off, helping drive these cancers" (Boltz 2014). The OTX015 us used to inhibit the proteins, and currently a study is being undergone to determine how much a OTX015 should be give to a patient and when. This is taken orally by patients "with hematologic malignancies"(Boltz 2014).
In terms of results, scientists have found that many lymphoma and leukemia patients are responding very well to this type of therapy. Scientists had 42 patients in their latest clinical trial, with half battling lymphoma and leukemia while the other half battled other hematologic malignancies. With each group, scientists gave patients different doses as well as giving them the medication on different schedules. Many participants were very successful when using the therapy.
Overall, I learned a lot about how epigenetic therapy is being used in the real world. An additional question that I have is if there is any additional research going on about other cancers? Given the success of this clinical trial, I am sure that it would benefit so many other patients suffering through different types of cancers.
Boltz, K. (2014, April 22). Epigenetic therapy clinically active against several blood cancers. Retrieved March 26, 2015, from http://www.oncologynurseadvisor.com/epigenetic-therapy-clinically-active-against-several-blood-cancers/article/343509/
Epigenetics [Motion picture]. (2007). PBS.
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